Annals of Advanced Biomedical Sciences (AABSc) - Medwin Publishers

Aggregation of misfolded proteins is a hallmark of many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and polyglutamine (polyQ) diseases. Clearance of misfolded proteins in the cell relies on the ubiquitin-proteasome system (UPS) and the autophagy-lysosome system. Since their discoveries, the UPS and autophagy were once thought to be independent of each other in terms of components, mechanisms and substrate selectivity. The UPS was believed to be responsible for degrading soluble proteins, whereas autophagy for degrading insoluble protein aggregates. However, recent studies have demonstrated that the insoluble protein aggregates may not be cytotoxic. By contrast, after deaggregation, multimers and microaggregates may still be present in the cell causing cytotoxicity. The UPS is incapable of degrading these soluble and semi-soluble species, and the vital task of degradation these toxic species rests upon the autophagy-lysos...

Cervical intraepithelial neoplastic grads1 were studied by flexible endoscopy obtaining five images: First image obtaining using white light the second and third image obtaining by blue, green narrow band image respectively by the special technique of endoscopy the fourth image was obtaining after that acetic acid was applied lastly, the iodine stain is applied and the fifth image was recorded after end of examination the five image were recorded and reviewed to be studied in correlation with cytology and histopathology results to be obtaining accurate diagnosis for CIN1.  Go through link for full article ↡ https://medwinpublishers.com/AABSc/AABSc16000127.pdf

Models that mimic the angiogenesis initial processes, as adhesion, migration, proliferation and tubulogenesis, are extremely valuable for investigating the action of new anti-cancer drugs. There still is a need for an angiogenesis model that reflects in vivo environment. To address this challenge, we developed a 3D matrix well-defined based on covalently immobilization of heparin (HEP) on bacterial nanocellulose (BNC) hydrogels. Successful immobilization was confirmed by qualitative and quantification analysis. Human umbilical vein endothelial cells (HUVECs) were seeded on bottom and top surfaces of BNC and BNC-HEP hydrogels and cells behavior were analyzed. The bottom surfaces of BNC-HEP hydrogels were able to support cell adhesion and promote proliferation and tubulogenesis formation. Results here presented indicate that the tubulogenesis process could be controlled by physico-chemical properties of the developed hydrogel. The interaction between the bioactive molecule, heparin, an...

Amitraz is a pesticide used in agriculture and public health to control insects, weeds, animals, and vectors of disease. Although the use of pesticides is of benefit in general, abuse of the pesticides is harmful due to their potential toxicity to humans and animals. Present study examined the effect of the pesticide on the male reproductive parameters of the male albino rats. 20 rats were grouped into four. Group 1 was control, Group 2 was given low dose Amitraz, Group 3 was median dose, and Group 4 was high dose. The administration was for a period of 21 days. Results showed that Amitraz has dose dependent toxicity effect on the reproductive parameter of the rat. Amitraz is toxic to the reproductive parameters of the albino rat, and could lower sperm concentration, sperm motility, and sperm morphology. By implication, Amitraz is toxic to the reproductive system and could cause infertility in male. Go through below link ⬇️   https://medwinpublishers.com/AABSc/AABSc16000125.pd...

Introduction: Hypertension is one of the highly growing chronic health challenges worldwide causing a significant number of deaths and cardiovascular complications. The prevalence of the condition in Ethiopia was estimated to be 19.5% with an urban and rural subgroup proportion of 25.7% and 14.7% respectively. This study was conducted to assess the pattern of prescribing antihypertensive medications and factors associated with BP target meeting among persons with hypertension in Federal Police Referral Hospital. Method: An institution based cross sectional study was conducted from 15th October 2016 to 15th January 2017. A systematic random sampling technique was employed in selecting the study participants. Data was collected using a semi-structured interview of study participants and visiting medication records. SPSS version 20 was used for data entry and analysis. Results: Of the 330 subjects required to be included in the study, 318 (96.4%) fulfilled the inclusion criteria and wer...

The relation of normal body temperature with stress eating was aim of present research. 125 subjects took part in present research, where their normal body temperature measured. Thermometer is widely used to measure body temperature. The normal temperature of body is in between 36.5–37.5°C (97.7–99.5°F). The overeating during stress and tension is called stress tension. The unhealthy and junk foods are also connected with stress eating. The 125 students take part in this study. They measured their body temperature by thermometer and check that there is any relation of temperature with stress eating. This was resulted from current study that normal body temperature has no effect on stress eating. Go through the below link for full article https://medwinpublishers.com/AABSc/AABSc16000123.pdf